IL-1 is required for tumor invasiveness and angiogenesis

Here, we describe that microenvironmental IL-1β and, to a lesser extent, IL-1α are required for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1β knockout (KO) mice, local tumor or lung metastases of B16 melanoma cells were not observed compared with WT mice. Angiogenesis was...

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Bibliografiske detaljer
Main Authors: Voronov, Elena, Shouval, Dror S., Krelin, Yakov, Cagnano, Emanuela, Benharroch, Daniel, Iwakura, Yoichiro, Dinarello, Charles A., Apte, Ron N.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC151394/
https://ncbi.nlm.nih.gov/pubmed/12598651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437939100
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