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Intranasal administration of the growth compromised HSV-2 vector ΔRR prevents kainate induced seizures and neuronal loss in rats and mice
Identification of targets and delivery platforms for gene therapy of neurodegenerative disorders is a clinical challenge. We describe a novel paradigm in which the neuroprotective gene is the herpes simplex virus type 2 (HSV-2) anti-apoptotic gene ICP10PK and the vector is the growth compromised HSV...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1513123/ https://ncbi.nlm.nih.gov/pubmed/16500153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2005.12.013 |
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