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Intranasal administration of the growth compromised HSV-2 vector ΔRR prevents kainate induced seizures and neuronal loss in rats and mice

Identification of targets and delivery platforms for gene therapy of neurodegenerative disorders is a clinical challenge. We describe a novel paradigm in which the neuroprotective gene is the herpes simplex virus type 2 (HSV-2) anti-apoptotic gene ICP10PK and the vector is the growth compromised HSV...

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Autori principali: Laing, Jennifer M., Gober, Michael D., Golembewski, Erin K., Thompson, Scott M., Gyure, Kymberly A., Yarowsky, Paul J., Aurelian, Laure
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1513123/
https://ncbi.nlm.nih.gov/pubmed/16500153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2005.12.013
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