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Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface
Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an autosomal recessive disorder of sterol trafficking. To determine the site of action of ABCG5 and ABCG8, we expressed recombinant, epitope-tagged mouse ABCG5 and ABCG8 in cultured cells. Both ABCG5 and ABCG8 underwent...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151110/ https://ncbi.nlm.nih.gov/pubmed/12208867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI16000 |
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