The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis

The Polycomb-group (PcG) gene Rae28 is a mammalian homologue of the Drosophila gene polyhomeotic. PcG genes are known to maintain transcription states, once initiated, probably by regulating chromatin structure. Since homozygous Rae28-deficient (Rae28(–/–)) mice displayed cardiac anomalies similar t...

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Detalhes bibliográficos
Main Authors: Shirai, Manabu, Osugi, Tomoaki, Koga, Hideyuki, Kaji, Yoshikazu, Takimoto, Eiki, Komuro, Issei, Hara, Junichi, Miwa, Takeshi, Yamauchi-Takihara, Keiko, Takihara, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151044/
https://ncbi.nlm.nih.gov/pubmed/12122109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14839
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