Inhibition by SK&F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes.

1. By use of whole cell patch-clamp and Indo-1 fluorescence studies of the Jurkat T leukaemic cell line, we show that the new organic antagonist of receptor-mediated Ca2+ entry, SK&F 96365, inhibits the T cell Ca2+ current in a dose-dependent fashion, with an IC50 of 12 microM. 2. SK&F 96365...

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Main Authors: Chung, S C, McDonald, T V, Gardner, P
Formato: Artigo
Idioma:Inglês
Publicado: 1994
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510420/
https://ncbi.nlm.nih.gov/pubmed/7858878
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