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The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.
1. The anticonvulsant and behavioural effects of the glycine/NMDA receptor partial agonist, L-687,414 (R(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one) have been investigated in rodents. 2. L-687,414 dose-dependently antagonized seizures induced by N-methyl-D,L- aspartic acid (NMDLA, ED50 = 19....
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Main Authors: | , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
1994
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1510413/ https://ncbi.nlm.nih.gov/pubmed/7858861 |
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