The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.

1. The anticonvulsant and behavioural effects of the glycine/NMDA receptor partial agonist, L-687,414 (R(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one) have been investigated in rodents. 2. L-687,414 dose-dependently antagonized seizures induced by N-methyl-D,L- aspartic acid (NMDLA, ED50 = 19....

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Detalhes bibliográficos
Main Authors: Tricklebank, M D, Bristow, L J, Hutson, P H, Leeson, P D, Rowley, M, Saywell, K, Singh, L, Tattersall, F D, Thorn, L, Williams, B J
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510413/
https://ncbi.nlm.nih.gov/pubmed/7858861
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