Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance

The Th1 cytokines IL-2 and IFN-γ, which inhibit T cell proliferation and promote activation induced cell death, may be required to diminish alloreactive T cell numbers and to foster tolerance across full allogeneic barriers. However, we hypothesized that these cytokines might be dispensable when the...

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Hauptverfasser: Kishimoto, Koji, Sandner, Sigrid, Imitola, Jaime, Sho, Masayuki, Li, Yongsheng, Langmuir, Peter B., Rothstein, David M., Strom, Terry B., Turka, Laurence A., Sayegh, Mohamed H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150996/
https://ncbi.nlm.nih.gov/pubmed/12045261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14947
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