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Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells
We studied the role of protein kinase C isoform PKCδ in ceramide (Cer) formation, as well as in the mitochondrial apoptosis pathway induced by anticancer drugs in prostate cancer (PC) cells. Etoposide and paclitaxel induced Cer formation and apoptosis in PKCδ-positive LNCaP and DU145 cells but not i...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150911/ https://ncbi.nlm.nih.gov/pubmed/11901191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14146 |
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