Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1α and VEGF

Acute intensive insulin therapy is an independent risk factor for diabetic retinopathy. Here we demonstrate that acute intensive insulin therapy markedly increases VEGF mRNA and protein levels in the retinae of diabetic rats. Retinal nuclear extracts from insulin-treated rats contain higher hypoxia-...

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Autors principals: Poulaki, Vassiliki, Qin, Wenying, Joussen, Antonia M., Hurlbut, Peter, Wiegand, Stanley J., Rudge, John, Yancopoulos, George D., Adamis, Anthony P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC150907/
https://ncbi.nlm.nih.gov/pubmed/11901189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13776
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