Disruption of Cell Cycle Kinetics by Benzo[a]pyrene: Inverse Expression Patterns of BRCA-1 and p53 in MCF-7 Cells Arrested in S and G(2)

The effects of a ligand of the aromatic hydrocarbon receptor (AhR), benzo[a]pyrene (B[a]P), and its metabolite, BPDE (7r,8t-dihydroxy-9t,10t-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene), on BRCA-1 levels and cell cycle kinetics were determined in MCF-7 breast cancer cells. Exposure of asynchronous MCF-...

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Hauptverfasser: Jeffy, Brandon D, Chen, Eddy J, Gudas, Jean M, Romagnolo, Donato F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature America, Inc. 2000
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507983/
https://ncbi.nlm.nih.gov/pubmed/11191113
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