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Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac ischemia, and exhausted skeletal muscles are accompanied by local tissue acidosis. In such acidotic states, extracellular protons provoke the pain by opening cation channels in nociceptors. It is generally believ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150796/ https://ncbi.nlm.nih.gov/pubmed/12393854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15709 |
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