Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this horm...

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Hauptverfasser: Farooqi, I. Sadaf, Matarese, Giuseppe, Lord, Graham M., Keogh, Julia M., Lawrence, Elizabeth, Agwu, Chizo, Sanna, Veronica, Jebb, Susan A., Perna, Francesco, Fontana, Silvia, Lechler, Robert I., DePaoli, Alex M., O’Rahilly, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150795/
https://ncbi.nlm.nih.gov/pubmed/12393845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15693
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