Mice Lacking the 68-Amino-Acid, Mammal-Specific N-Terminal Extension of WT1 Develop Normally and Are Fertile

Mutations in the Wilms' tumor 1 gene, WT1, cause pediatric nephroblastoma and the severe genitourinary disorders of Frasier and Denys-Drash syndromes. High levels of WT1 expression are found in the developing kidney, uterus, and testis—consistent with this finding, the WT1 knockout mouse demonstrate...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Miles, Colin G., Slight, Joan, Spraggon, Lee, O'Sullivan, Maureen, Patek, Charles, Hastie, Nicholas D.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2003
Fag:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12640141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.7.2608-2613.2003
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