Mutation of Single Hydrophobic Residue I27, L35, F39, L58, L65, L67, or L71 in the N Terminus of VP5 Abolishes Interaction with the Scaffold Protein and Prevents Closure of Herpes Simplex Virus Type 1 Capsid Shells

Protein-protein interactions drive the assembly of the herpes simplex virus type 1 (HSV-1) capsid. A key interaction occurs between the C-terminal tail of the scaffold protein (pre-22a) and the major capsid protein (VP5). Previously (Z. Hong, M. Beaudet-Miller, J. Durkin, R. Zhang, and A. D. Kwong,...

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Detaylı Bibliyografya
Asıl Yazarlar: Walters, Jewell N., Sexton, Gerry L., McCaffery, J. Michael, Desai, Prashant
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2003
Konular:
Structure and Assembly
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC150648/
https://ncbi.nlm.nih.gov/pubmed/12634364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.7.4043-4059.2003
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