Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C

Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37°C, but not 4°C. Binding of hAPN may therefore trigger conformation...

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Main Authors: Breslin, Jamie J., Mørk, Irene, Smith, M. K., Vogel, Lotte K., Hemmila, Erin M., Bonavia, Aurelio, Talbot, Pierre J., Sjöström, Hans, Norén, Ove, Holmes, Kathryn V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC150646/
https://ncbi.nlm.nih.gov/pubmed/12634402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.7.4435-4438.2003
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