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Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the generation and analysis of mice carrying a null mutation in the occludin gene. Occludin −/− mice were born with no gross phenotype in the expec...

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Auteurs principaux: Saitou, Mitinori, Furuse, Mikio, Sasaki, Hiroyuki, Schulzke, Jörg-Dieter, Fromm, Michael, Takano, Hiroshi, Noda, Tetsuo, Tsukita, Shoichiro
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC15062/
https://ncbi.nlm.nih.gov/pubmed/11102513
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