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Mutation of Cyclin/cdk Phosphorylation Sites in HsCdc6 Disrupts a Late Step in Initiation of DNA Replication in Human Cells

Cyclin-dependent kinases (Cdk) are essential for promoting the initiation of DNA replication, presumably by phosphorylating key regulatory proteins that are involved in triggering the G1/S transition. Human Cdc6 (HsCdc6), a protein required for initiation of DNA replication, is phosphorylated by Cdk...

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Hlavní autoři: Herbig, Utz, Griffith, Jason W., Fanning, Ellen
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC15061/
https://ncbi.nlm.nih.gov/pubmed/11102512
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