Microtubule-Targeting Drugs Induce Bcl-2 Phosphorylation and Association with Pin1

Bcl-2 is a critical suppressor of apoptosis that is overproduced in many types of cancer. Phosphorylation of the Bcl-2 protein is induced on serine residues in tumor cells arrested by microtubule-targeting drugs (paclitaxel, vincristine, nocodazole) and has been associated with inactivation of antia...

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Bibliographic Details
Main Authors: Pathan, Nuzhat, Aime-sempe, Christine, Kitada, Shinichi, Haldar, Subrata, Reed, John C
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2001
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1505024/
https://ncbi.nlm.nih.gov/pubmed/11326318
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