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Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
Drug delivery and penetration into neoplastic cells distant from tumor vessels are critical for the effectiveness of solid-tumor chemotherapy. We have found that targeted delivery to tumor vessels of picogram doses of TNF-α (TNF), a cytokine able to alter endothelial barrier function and tumor inter...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150417/ https://ncbi.nlm.nih.gov/pubmed/12189241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15223 |
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