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UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells
Endothelin-1 (ET-1), a peptide that is secreted by keratinocytes in the skin in response to ultraviolet irradiation, is a ligand for the endothelin-B (ET(B)) receptor. Blockade of this receptor inhibits melanoma cell growth and induces cell death in vivo and in vitro. Additionally, ET(B) is a melano...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150409/ https://ncbi.nlm.nih.gov/pubmed/12189238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13729 |
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