ACAT1 and ACAT2 Membrane Topology Segregates a Serine Residue Essential for Activity to Opposite Sides of the Endoplasmic Reticulum Membrane

A second form of the enzyme acyl-CoA:cholesterol acyltransferase, ACAT2, has been identified. To explore the hypothesis that the two ACAT enzymes have separate functions, the membrane topologies of ACAT1 and ACAT2 were examined. A glycosylation reporter and FLAG epitope tag sequence was appended to...

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Detalhes bibliográficos

Publicado no:	Mol Biol Cell
Principais autores:	Joyce, Charles W., Shelness, Gregory S., Davis, Matthew A., Lee, Richard G., Skinner, Kelly, Anderson, Richard A., Rudel, Lawrence L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15029/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11071899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.11.3675
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