TRAIL Activates a Caspase 9/7-Dependent Pathway in Caspase 8/10-Defective SK-N-SH Neuroblastoma Cells with Two Functional End Points: Induction of Apoptosis and PGE(2) Release

Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of malignant cell types. In this study, we demonstrated that TRAIL induced a moderate but significant in...

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Bibliografiske detaljer
Main Authors: Zauli, Giorgio, Milani, Daniela, Rimondi, Erika, Baldini, Giovanna, Nicolin, Vanessa, Grill, Vittorio, Secchiero, Paola
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502615/
https://ncbi.nlm.nih.gov/pubmed/14670183
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