Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

The mechanisms of malignant cell transformation mediated by the oncogenic, chimeric nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) tyrosine kinase remain only partially understood. Here we report that the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells secrete IL-10 and TGF-β and express FoxP3,...

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Main Authors: Kasprzycka, Monika, Marzec, Michal, Liu, Xiaobin, Zhang, Qian, Wasik, Mariusz A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502562/
https://ncbi.nlm.nih.gov/pubmed/16766651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603507103
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