TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis

Asbestos is the main cause of human malignant mesothelioma (MM). In vivo, macrophages phagocytize asbestos and, in response, release TNF-α and other cytokines that contribute to carcinogenesis through unknown mechanisms. In vitro, asbestos does not induce transformation of primary human mesothelial...

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Detalhes bibliográficos
Main Authors: Yang, Haining, Bocchetta, Maurizio, Kroczynska, Barbara, Elmishad, Amira G., Chen, Yuanbin, Liu, Zemin, Bubici, Concetta, Mossman, Brooke T., Pass, Harvey I., Testa, Joseph R., Franzoso, Guido, Carbone, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502469/
https://ncbi.nlm.nih.gov/pubmed/16798876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604008103
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