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Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP)
The general transcription factor TFIID, composed of the TATA box-binding protein (TBP) and 14 TBP-associated factors (TAFs), is important for both basal and regulated transcription by RNA polymerase II. Although it is well known that the TAF N-terminal domain (TAND) at the amino-terminus of the TAF1...
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Main Authors: | , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
Oxford University Press
2003
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150217/ https://ncbi.nlm.nih.gov/pubmed/12582246 |
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