A(3) Adenosine Receptors Modulate Hypoxia-Inducible Factor-1α Expression in Human A375 Melanoma Cells

Hypoxia-inducible factor-1 (HIF-1) is a key regulator of genes crucial to many aspects of cancer biology. The purine nucleoside, adenosine, accumulates within many tissues under hypoxic conditions, including that of tumors. Because the levels of both HIF-1 and adenosine are elevated within the hypox...

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Main Authors: Merighi, Stefania, Benini, Annalisa, Mirandola, Prisco, Gessi, Stefania, Varani, Katia, Leung, Edward, MacLennan, Stephen, Baraldi, Pier Giovanni, Borea, Pier Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502026/
https://ncbi.nlm.nih.gov/pubmed/16242072
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