Downmodulation of E1A Protein Expression as a Novel Strategy to Design Cancer-Selective Adenoviruses

Oncolytic adenoviruses are being tested as potential therapies for human malignant tumors, including gliomas. Here we report for the first time that a mutation in the E1A gene results in low levels of E1A protein, conditioning the replication of mutant adenoviruses specifically to cancer cells. In t...

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Detalhes bibliográficos
Main Authors: Jiang, Hong, Alemany, Ramon, Gomez-Manzano, Candelaria, Medrano, Diana R, Lemoine, Michael G, Olson, Melissa V, Alonso, Marta M, Lee, Ok-Hee, Conrad, Charles C, Yung, W K Alfred, Fueyo, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501891/
https://ncbi.nlm.nih.gov/pubmed/16207474
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