A Novel Targeted Therapy of Leydig and Granulosa Cell Tumors through the Luteinizing Hormone Receptor Using a Hecate-Chorionic Gonadotropin β Conjugate in Transgenic Mice

We investigated the antitumoral efficacy, endocrine consequences, and molecular mechanisms underlying cell death induced by the Hecate-chorionic gonadotropin (CG)β conjugate, a fusion protein of a 23-amino acid lytic peptide Hecate with a 15-amino acid (81–95) fragment of the human CGβ chain. Transg...

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Hauptverfasser: Bodek, Gabriel, Vierre, Susanna, Rivero-Müller, Adolfo, Huhtaniemi, Ilpo, Ziecik, Adam J, Rahman, Nafis A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2005
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501163/
https://ncbi.nlm.nih.gov/pubmed/15967102
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