Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability

An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding β-catenin), AXIN2, TCF4, and WISP3] and three...

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Bibliographic Details
Main Authors: Thorstensen, Lin, Lind, Guro E, Løvig, Tone, Diep, Chieu B, Meling, Gunn I, Rognum, Torleiv O, Lothe, Ragnhild A
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2005
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501125/
https://ncbi.nlm.nih.gov/pubmed/15802015
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