X-ray crystal structure of MENT: evidence for functional loop–sheet polymers in chromatin condensation

Most serpins are associated with protease inhibition, and their ability to form loop–sheet polymers is linked to conformational disease and the human serpinopathies. Here we describe the structural and functional dissection of how a unique serpin, the non-histone architectural protein, MENT (Myeloid...

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Detalhes bibliográficos
Main Authors: McGowan, Sheena, Buckle, Ashley M, Irving, James A, Ong, Poh Chee, Bashtannyk-Puhalovich, Tanya A, Kan, Wan-Ting, Henderson, Kate N, Bulynko, Yaroslava A, Popova, Evgenya Y, Smith, A Ian, Bottomley, Stephen P, Rossjohn, Jamie, Grigoryev, Sergei A, Pike, Robert N, Whisstock, James C
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500978/
https://ncbi.nlm.nih.gov/pubmed/16810322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601201
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