DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

Infection of T cells by HIV-1 can occur through binding of virus to dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) on dendritic cells and transfer of virus to CD4(+) T cells. Here we show that a subset of B cells in the blood and tonsils of normal donors expressed DC-SIGN, and th...

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Hlavní autoři: Rappocciolo, Giovanna, Piazza, Paolo, Fuller, Craig L, Reinhart, Todd A, Watkins, Simon C, Rowe, David T, Jais, Mariel, Gupta, Phalguni, Rinaldo, Charles R
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2006
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500807/
https://ncbi.nlm.nih.gov/pubmed/16839201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0020070
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