Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C

Macropinocytosis results from the closure of lamellipodia generated by membrane ruffling, thereby reflecting cortical actin dynamics. Both transformation of Rat-1 fibroblasts by v-Src or K-Ras and stable transfection for expression of dominant-positive, wild-type phosphoinositide 3-kinase (PI3K) reg...

Full description

Saved in:
Bibliographic Details
Main Authors: Amyere, Mustapha, Payrastre, Bernard, Krause, Ulrike, Smissen, Patrick Van Der, Veithen, Alex, Courtoy, Pierre J.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2000
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC15006/
https://ncbi.nlm.nih.gov/pubmed/11029048
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items