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Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

The inhibitory Smad7, a direct target gene for transforming growth factor-β (TGF-β), mediates TGF-β1–induced apoptosis in several cell types. Herein, we report that apoptosis of human prostate cancer PC-3U cells induced by TGF-β1 or Smad7 overexpression is caused by a specific activation of the p38...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Edlund, Sofia, Bu, Shizhong, Schuster, Norbert, Aspenström, Pontus, Heuchel, Rainer, Heldin, Nils-Erik, ten Dijke, Peter, Heldin, Carl-Henrik, Landström, Maréne
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Cell Biology 2003
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Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149990/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12589052/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.02-03-0037
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