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Deletion of the p66(Shc) longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet
Several experimental and clinical studies have shown that oxidized low-density lipoprotein and oxidation-sensitive mechanisms are central in the pathogenesis of vascular dysfunction and atherogenesis. Here, we have used p66(Shc−/−) and WT mice to investigate the effects of high-fat diet on both syst...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The National Academy of Sciences
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149967/ https://ncbi.nlm.nih.gov/pubmed/12571362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0336359100 |
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