Deletion of the p66(Shc) longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet

Several experimental and clinical studies have shown that oxidized low-density lipoprotein and oxidation-sensitive mechanisms are central in the pathogenesis of vascular dysfunction and atherogenesis. Here, we have used p66(Shc−/−) and WT mice to investigate the effects of high-fat diet on both syst...

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Bibliographic Details
Main Authors: Napoli, Claudio, Martin-Padura, Ines, de Nigris, Filomena, Giorgio, Marco, Mansueto, Gelsomina, Somma, Pasquale, Condorelli, Mario, Sica, Giacomo, De Rosa, Gaetano, Pelicci, PierGiuseppe
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149967/
https://ncbi.nlm.nih.gov/pubmed/12571362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0336359100
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