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cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1

The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant ph...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Leonard, A. Soren, Yermolaieva, Olena, Hruska-Hageman, Alesia, Askwith, Candice C., Price, Margaret P., Wemmie, John A., Welsh, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149953/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12578970/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252782799
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