Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

During organogenesis, immunosurveillance, and inflammation, chemokines selectively recruit leukocytes by activating seven-transmembrane-spanning receptors. It has been suggested that an important component of this process is the formation of a haptotactic gradient by immobilization of chemokines on...

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Bibliographic Details
Main Authors: Proudfoot, Amanda E. I., Handel, Tracy M., Johnson, Zoë, Lau, Elaine K., LiWang, Patricia, Clark-Lewis, Ian, Borlat, Frédéric, Wells, Timothy N. C., Kosco-Vilbois, Marie H.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149928/
https://ncbi.nlm.nih.gov/pubmed/12571364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0334864100
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