Packing helices in proteins by global optimization of a potential energy function

An efficient method has been developed for packing α-helices in proteins. It treats α-helices as rigid bodies and uses a simplified Lennard–Jones potential with Miyazawa–Jernigan contact-energy parameters to describe the interactions between the α-helical elements in this coarse-grained system. Glob...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Nanias, Marian, Chinchio, Maurizio, Pillardy, Jarosław, Ripoll, Daniel R., Scheraga, Harold A.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12571353/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252760199
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