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Exonuclease-Deficient Polymerase Mutant of Herpes Simplex Virus Type 1 Induces Altered Spectra of Mutations

The effect of exonuclease activity of the herpes simplex virus DNA polymerase (Pol) on DNA replication fidelity was examined by using the supF mutagenesis assay. The recombinants with exonuclease-deficient Pol, containing an integrated supF gene in the thymidine kinase locus (tk), exhibited supF mut...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hwang, Ying T., Hwang, Charles B. C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC149784/
https://ncbi.nlm.nih.gov/pubmed/12584319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.5.2946-2955.2003
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