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Dissection of the XChk1 Signaling Pathway in Xenopus laevis Embryos

Checkpoint pathways inhibit cyclin-dependent kinases (Cdks) to arrest cell cycles when DNA is damaged or unreplicated. Early embryonic cell cycles of Xenopus laevis lack these checkpoints. Completion of 12 divisions marks the midblastula transition (MBT), when the cell cycle lengthens, acquiring gap...

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Autori principali: Kappas, Nicholas C., Savage, Pamela, Chen, Katherine C., Walls, Allan T., Sible, Jill C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC14978/
https://ncbi.nlm.nih.gov/pubmed/10982403
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