A Role for Both Ets and C/EBP Transcription Factors and mRNA Stabilization in the MAPK-dependent Increase in p21 (Cip-1/WAF1/mda6) Protein Levels in Primary Hepatocytes

In primary hepatocytes and HepG2 hepatoma cells, prolonged activation of the p42/44 mitogen-activated protein kinase (MAPK) pathway is associated with a reduction in DNA synthesis, mediated by increased expression of the cyclin-dependent kinase inhibitor protein p21 (Cip-1/WAF1/mda6) (p21). This stu...

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Main Authors: Park, Jong-Sung, Qiao, Liang, Gilfor, Donna, Yang, Ming Yan, Hylemon, Philip B., Benz, Christopher, Darlington, Gretchen, Firestone, Gary, Fisher, Paul B., Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC14965/
https://ncbi.nlm.nih.gov/pubmed/10982390
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