Real-Time PCR Assay for Rapid and Accurate Detection of Point Mutations Conferring Resistance to Clarithromycin in Helicobacter pylori

The main cause of failure of Helicobacter pylori eradication therapy is resistance to clarithromycin. The resistance is due to three point mutations in two positions on the 23S rRNA (A2142C, A2142G, and A2143G). Our aim was to develop a rapid and accurate method to detect these mutations directly on...

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Bibliographic Details
Main Authors: Oleastro, Monica, Ménard, Armelle, Santos, Adriana, Lamouliatte, Hervé, Monteiro, Lurdes, Barthélémy, Philippe, Mégraud, Francis
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Bacteriology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149634/
https://ncbi.nlm.nih.gov/pubmed/12517879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.41.1.397-402.2003
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