Chimeric and Pseudotyped Parvoviruses Minimize the Contamination of Recombinant Stocks with Replication-Competent Viruses and Identify a DNA Sequence That Restricts Parvovirus H-1 in Mouse Cells

Recent studies demonstrated the ability of the recombinant autonomous parvoviruses MVMp (fibrotropic variant of the minute virus of mice) and H-1 to transduce therapeutic genes in tumor cells. However, recombinant vector stocks are contaminated by replication-competent viruses (RCVs) generated durin...

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Autores principales: Wrzesinski, Claudia, Tesfay, Lia, Salomé, Nathalie, Jauniaux, Jean-Claude, Rommelaere, Jean, Cornelis, Jan, Dinsart, Christiane
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC149498/
https://ncbi.nlm.nih.gov/pubmed/12610161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.6.3851-3858.2003
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