Activation of the Early B-Cell-Specific mb-1 (Ig-α) Gene by Pax-5 Is Dependent on an Unmethylated Ets Binding Site

Methylation of cytosine in CpG dinucleotides promotes transcriptional repression in mammals by blocking transcription factor binding and recruiting methyl-binding proteins that initiate chromatin remodeling. Here, we use a novel cell-based system to show that retrovirally expressed Pax-5 protein act...

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Hlavní autoři: Maier, Holly, Colbert, Jeff, Fitzsimmons, Daniel, Clark, Dawn R., Hagman, James
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Transcriptional Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC149480/
https://ncbi.nlm.nih.gov/pubmed/12612069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.1946-1960.2003
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