A Raf-1 Mutant That Dissociates MEK/Extracellular Signal-Regulated Kinase Activation from Malignant Transformation and Differentiation but Not Proliferation

It is widely thought that the biological outcomes of Raf-1 activation are solely attributable to the activation of the MEK/extracellular signal-regulated kinase (ERK) pathway. However, an increasing number of reports suggest that some Raf-1 functions are independent of this pathway. In this report w...

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Main Authors: Dhillon, Amardeep S., Meikle, Sharon, Peyssonnaux, Carole, Grindlay, Joan, Kaiser, Christian, Steen, Helge, Shaw, Peter E., Mischak, Harald, Eychène, Alain, Kolch, Walter
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC149463/
https://ncbi.nlm.nih.gov/pubmed/12612072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.6.1983-1993.2003
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