Dominant Negative Dimerization of a Mutant Homeodomain Protein in Axenfeld-Rieger Syndrome
Axenfeld-Rieger syndrome is an autosomal-dominant disorder caused by mutations in the PITX2 homeodomain protein. We have studied the mechanism underlying the dominant negative K88E mutation, which occurs at position 50 of the homeodomain. By using yeast two-hybrid and in vitro pulldown assays, we ha...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12612071/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.6.1968-1982.2003 |
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