A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus

The genes encoding 14α-sterol demethylases (cyp51A and cyp51B) were analyzed in 12 itraconazole (ITC)-resistant and three ITC-susceptible clinical isolates of Aspergillus fumigatus. Six ITC-resistant strains exhibited a substitution of another amino acid for glycine at position 54, which is located...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Diaz-Guerra, T. M., Mellado, E., Cuenca-Estrella, M., Rodriguez-Tudela, J. L.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2003
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149335/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.1120-1124.2003
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