A Point Mutation in the 14α-Sterol Demethylase Gene cyp51A Contributes to Itraconazole Resistance in Aspergillus fumigatus

The genes encoding 14α-sterol demethylases (cyp51A and cyp51B) were analyzed in 12 itraconazole (ITC)-resistant and three ITC-susceptible clinical isolates of Aspergillus fumigatus. Six ITC-resistant strains exhibited a substitution of another amino acid for glycine at position 54, which is located...

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Bibliographic Details
Main Authors: Diaz-Guerra, T. M., Mellado, E., Cuenca-Estrella, M., Rodriguez-Tudela, J. L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149335/
https://ncbi.nlm.nih.gov/pubmed/12604551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.3.1120-1124.2003
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