Structure-Based Design and Engineering of a Nontoxic Recombinant Pokeweed Antiviral Protein with Potent Anti-Human Immunodeficiency Virus Activity

A molecular model of pokeweed antiviral protein (PAP)-RNA interactions was used to rationally engineer FLP-102((151)AA(152)) and FLP-105((191)AA(192)) as nontoxic PAPs with potent anti-human immunodeficiency virus (anti-HIV) activities. FLP-102 and FLP-105 have been produced in Escherichia coli and...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Uckun, Fatih M., Rajamohan, Francis, Pendergrass, Sharon, Ozer, Zahide, Waurzyniak, Barbara, Mao, Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12604541/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.3.1052-1061.2003
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