Structure-Based Design and Engineering of a Nontoxic Recombinant Pokeweed Antiviral Protein with Potent Anti-Human Immunodeficiency Virus Activity

A molecular model of pokeweed antiviral protein (PAP)-RNA interactions was used to rationally engineer FLP-102((151)AA(152)) and FLP-105((191)AA(192)) as nontoxic PAPs with potent anti-human immunodeficiency virus (anti-HIV) activities. FLP-102 and FLP-105 have been produced in Escherichia coli and...

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Detalhes bibliográficos
Main Authors: Uckun, Fatih M., Rajamohan, Francis, Pendergrass, Sharon, Ozer, Zahide, Waurzyniak, Barbara, Mao, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149289/
https://ncbi.nlm.nih.gov/pubmed/12604541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.3.1052-1061.2003
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