Mutations lowering the phosphatase activity of HPr kinase/phosphatase switch off carbon metabolism

The oligomeric bifunctional HPr kinase/P-Ser-HPr phosphatase (HprK/P) regulates many metabolic functions in Gram-positive bacteria by phosphorylating the phosphocarrier protein HPr at Ser46. We isolated Lactobacillus casei hprK alleles encoding mutant HprK/Ps exhibiting strongly reduced phosphatase,...

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Publikašuvnnas:	EMBO J
Váldodahkkit:	Monedero, Vicente, Poncet, Sandrine, Mijakovic, Ivan, Fieulaine, Sonia, Dossonnet, Valérie, Martin-Verstraete, Isabelle, Nessler, Sylvie, Deutscher, Josef
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Publishing Group 2001
Fáttát:	Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149165/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.3928
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